First, it's Yonge
Really, there's no reason to go east of Yonge unless you want to hit the church/Wellesley village (my guess is you don't swing that way) or St Lawrence (which is just east of Union station on Front St.). Some shady streets like Jarvis, Sherbourne and Parliament should probably be avoided between Queen and Bloor, but you really have no reason to venture that far east anyways. Not that it's that dangerous. Just some of the seedier areas.
If you're looking for some decent bars/restaurants go to the west of the intersection of Bloor/Spadina. If you're looking to catch a show I'd look here:
http://www.eyeweekly.com/music/musicchart there's a list of every venue in the city and who is playing where and when.
i don't know anything beyond what you've said here, so I can't be of much more help...
oh and hello cm
I can't wait until the day schools are over-funded and the military is forced to hold bake sales to buy planes.
"It's a great thing when you realize you still have the ability to surprise yourself. Makes you wonder what else you can do that you've forgotten about"